Identification and characterization of tumor and stromal derived liquid biopsy analytes in pancreatic ductal adenocarcinoma
Our liquid biopsy assay provides robust detection of cCAFs in mPDAC and mGI patients. The measurement of both circulatory stromal parameters, cCAFs and HA, adds valuable clinical information as they are associated with an unfavorable outcome in PDAC. These results highlight that stromal characteristics unique to PDAC could be leveraged to fill the current gap in discovering predictive biomarkers.
Authors
- Thilo Hackert (ORCID: https://orcid.org/0000-0002-7012-1196)
- Svenja Schneegans (ORCID: https://orcid.org/0000-0002-2684-790X)
- Kim C. Honselmann (ORCID: https://orcid.org/0000-0002-5699-2286)
- Julian Götze
- Thais Pereira‐Veiga (ORCID: https://orcid.org/0000-0002-4473-7608)
- Faik G. Uzunoglu
- Sven Peine
- Alina Busch
- Volker Spindler (ORCID: https://orcid.org/0000-0002-1302-5421)
- Klaus Pantel (ORCID: https://orcid.org/0000-0001-5736-2772)
- Joao Gorgulho (ORCID: https://orcid.org/0000-0003-1986-8208)
- K. Meißner (ORCID: https://orcid.org/0000-0002-1616-0856)
- Christine Nitschke (ORCID: https://orcid.org/0000-0002-4645-7909)
- Martin Schönrock
- Yassine Belloum (ORCID: https://orcid.org/0000-0003-2514-3713)
- Carsten Bokemeyer (ORCID: https://orcid.org/0000-0001-6071-7810)
- Jolanthe Kropidlowski
- Harriet Wikman (ORCID: https://orcid.org/0000-0001-6862-0888)
- Ronald Simon (ORCID: https://orcid.org/0000-0003-0158-4258)
- Marianne Sinn (ORCID: https://orcid.org/0000-0002-7155-1278)
- Jakob Robert Izbicki
- Arne Putscher
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital Schleswig-Holstein (DE)
- University Cancer Center Hamburg (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1186/s13046-024-03262-x
- Citations
- 6
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- Joachim Herz Stiftung
- ANGLE
- Universitätsklinikum Hamburg-Eppendorf