Sex and APOE genotype modulate neuropsychological profile and depression in temporal lobe epilepsy
These findings underscore the importance of considering both sex and APOE genotype when assessing cognitive performance in patients with temporal lobe epilepsy. The significant cognitive deficits we observed among females carrying the APOE ε4 allele highlight previously unexplored genetic and sex-related influences on cognition. This has potential implications for personalized therapeutic strategies, emphasizing the need for targeted assessment and intervention.
Authors
- Francesca Cavalcanti (ORCID: https://orcid.org/0000-0001-5769-4582)
- Annamaria Cerantonio
- Patrizia Spadafora (ORCID: https://orcid.org/0000-0001-5890-4561)
- Francesco Bruno (ORCID: https://orcid.org/0000-0003-1377-4489)
- Olivier Gallo
- Béatrice Gréco (ORCID: https://orcid.org/0000-0002-9020-3260)
- Gemma Di Palma
- Luigi Citrigno (ORCID: https://orcid.org/0000-0001-7410-7781)
- Francesca Condino (ORCID: https://orcid.org/0000-0001-7814-7799)
- Selene De Benedittis (ORCID: https://orcid.org/0000-0001-6340-8888)
- Maurizio Cundari (ORCID: https://orcid.org/0000-0002-4825-2130)
- Antonio Qualtieri (ORCID: https://orcid.org/0000-0002-9147-9752)
- Ida Veltri
- Mario L. Cuconati
Institutions
- Lund University (SE)
- Magna Graecia University (IT)
- Institute for Biomedical Research and Innovation (IT)
- Helsingborgs lasarett (SE)
- Mercatorum University (IT)
- Ospedale Maggiore di Lodi (IT)
- National Research Council (IT)
- University of Calabria (IT)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-01-16
- DOI
- https://doi.org/10.3389/fnins.2024.1514902
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47