Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis
We identify novel epigenetic alterations in IgG4-SC and PSC, with biological age acceleration in IgG4-SC, providing insights into disease pathogenesis, and highlight the role of genetic variation especially within the HLA region in shaping the methylome.
Authors
- Aleksandra Glapa-Nowak (ORCID: https://orcid.org/0000-0002-3017-0524)
- Emma Louise Culver (ORCID: https://orcid.org/0000-0001-9644-8392)
- Alexandra Noble (ORCID: https://orcid.org/0000-0002-6894-9672)
- Jack Satsangi (ORCID: https://orcid.org/0000-0002-6357-9684)
- Alessandra Geremia (ORCID: https://orcid.org/0000-0002-4847-9335)
- Silvia Cabras
- Rodrigo Motta (ORCID: https://orcid.org/0000-0002-8086-3513)
- J Nowak
- B M Flores
Institutions
- Poznan University of Medical Sciences (PL)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1186/s13148-024-01803-x
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- University of Oxford