Seizure network characterization by functional connectivity mapping and manipulation
Here, we demonstrate a paradigm for combining widefield calcium imaging with microstimulation, cortical ablation, and seizure mapping to determine how anatomical networks inform the propagation patterns of cortical seizures. These experiments can be extended to long-term tracking of epilepsy to study epileptogenesis in other cortical networks. Our proof-of-concept findings suggest that this paradigm may be useful in the development of novel therapies for drug-resistant epilepsy patients and can be extended to the study of other disorders involving brain networks.
Authors
- Jyun-you Liou (ORCID: https://orcid.org/0000-0003-4851-3676)
- Peijuan Luo
- Theodore H. Schwartz (ORCID: https://orcid.org/0000-0003-4464-7394)
- Daniel A. Surinach (ORCID: https://orcid.org/0000-0001-5643-9619)
- James E. Niemeyer (ORCID: https://orcid.org/0000-0002-5864-7777)
- Carmen Pons
- Hongtao Ma (ORCID: https://orcid.org/0000-0002-1583-0483)
- Shiqiang Wu
- Suhasa Bangalore Kodandaramaiah
Institutions
- University of Minnesota (US)
- Jilin University (CN)
- Cornell University (US)
- University of Chicago (US)
- First Hospital of Jilin University (CN)
- Neurological Surgery (US)
- Tongji Hospital (CN)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Neurophotonics
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1117/1.nph.12.s1.s14605
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Citizens United for Research in Epilepsy
- Weill Cornell Medical College