Association of Alzheimer’s Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics
Our findings suggest high AD genetic risk is not associated with more severe concussions or poor recovery in young adults. Future studies should attempt to replicate these findings in larger samples with longer follow-up using PRS calculated from diverse populations.
Authors
- Jason P. Mihalik (ORCID: https://orcid.org/0000-0001-6085-8322)
- Thomas W. McAllister (ORCID: https://orcid.org/0000-0003-0267-3076)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Brenna C. McDonald (ORCID: https://orcid.org/0000-0001-6895-4490)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Kevin M. Guskiewicz (ORCID: https://orcid.org/0000-0002-8682-2130)
- Steven P. Broglio (ORCID: https://orcid.org/0000-0002-2282-9325)
- Joshua Goldman (ORCID: https://orcid.org/0000-0001-7329-6285)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Yu‐Chien Wu (ORCID: https://orcid.org/0000-0003-1084-2634)
- Kaitlyn M. Dybing (ORCID: https://orcid.org/0000-0003-1790-4121)
- Jonathan C. Jackson
Institutions
- University of North Carolina at Chapel Hill (US)
- Uniformed Services University of the Health Sciences (US)
- University of California, Los Angeles (US)
- University of Michigan (US)
- Utah Valley Regional Medical Center (US)
- United States Air Force Academy (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Sports Medicine
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1007/s40279-024-02150-w
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- U.S. Department of Defense
- Eli Lilly and Company
- National Collegiate Athletic Association
- Siemens Medical Solutions USA
- Eisai
- National Institutes of Health
- Centers for Disease Control and Prevention
- Avid Radiopharmaceuticals
- National Heart, Lung, and Blood Institute