Development of Vitamin C-Enriched Oral Disintegration Films Using Chia Mucilage

Oral disintegration films (ODFs) offer a convenient alternative for administering active compounds with quick absorption, no need for water, customizable formulation, and promising pharmaceutical applications. This study aimed to develop chia mucilage films as a new polymer to carry vitamin C. Chia mucilage was extracted using the method of immersing the seeds in water, separated by vacuum filtration and using a sieve to remove the mucilaginous gel, then centrifuged and finally freeze-dried, with the mucilage obtained being used to produce films using the casting technique. The formulations included a control and a 1% vitamin C variant, with glycerol as a plasticizer. The produced films showed high solubility, pH close to the oral and a disintegration time of 53.17 s for the formulation with 1% vitamin C. The presence of vitamin C in the polymer matrix, as well as the interactions between them, were confirmed by DSC and FTIR spectra. On the first day of storage, after 1 min of reaction at 30 °C, the vitamin C concentration obtained was 477.50 mg/g, while at 40 °C was 411.28 mg/g. After 35 days of storage, the films showed a reduction in vitamin C concentration. Chia mucilage proved to be a promising polymer in the production of ODFs carrying vitamin C.