Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia
Our findings support the association of PRShp with aMCI/AD incidence and with global cognitive and memory decline over time. The PRS association was sex- and age-dependent, suggesting that these factors should be considered in genetic modelling for AD.
Authors
- Jean‐Charles Lambert (ORCID: https://orcid.org/0000-0003-0829-7817)
- Georgios M. Hadjigeorgiou (ORCID: https://orcid.org/0000-0001-5386-4273)
- Ioannis Liampas (ORCID: https://orcid.org/0000-0002-2958-5220)
- Efthimios Dardiotis (ORCID: https://orcid.org/0000-0003-2957-641X)
- Alex Hatzimanolis
- Niki Mourtzi (ORCID: https://orcid.org/0000-0002-8650-4239)
- Alfredo Ramı́rez (ORCID: https://orcid.org/0000-0003-4991-763X)
- Mary Yannakoulia (ORCID: https://orcid.org/0000-0003-2171-7337)
- Konstantinos Rouskas (ORCID: https://orcid.org/0000-0003-2549-6834)
- Mary H. Kosmidis (ORCID: https://orcid.org/0000-0001-8790-1220)
- Vasileios Siokas (ORCID: https://orcid.org/0000-0002-8664-5824)
- Sokratis Charisis (ORCID: https://orcid.org/0000-0001-6578-393X)
- Stefanos N. Sampatakakis (ORCID: https://orcid.org/0009-0009-7316-0471)
- Paraskevi Sakka
- Nikolaos Scarmeas
- Ioannis Foukarakis
Institutions
- University of Thessaly (GR)
- Inserm (FR)
- The University of Texas at San Antonio Health Science Center (US)
- University of Cologne (DE)
- National and Kapodistrian University of Athens (GR)
- Aristotle University of Thessaloniki (GR)
- Université de Lille (FR)
- University Hospital Bonn (DE)
- Institut Pasteur de Lille (FR)
- German Center for Neurodegenerative Diseases (DE)
- Centre Hospitalier Universitaire de Lille (FR)
- Harokopio University of Athens (GR)
- University of Cyprus (CY)
- University Hospital of Larissa (GR)
- Institute for Neurodegenerative Disorders (US)
- Centre for Research and Technology Hellas (GR)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Eginition Hospital (GR)
- Greek Association of Alzheimer's Disease and Related Disorders (GR)
- Columbia University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Geriatrics
- Published
- 2025-01-16
- DOI
- https://doi.org/10.3390/geriatrics10010014
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Alzheimer's Association