BCG-Induced DNA Methylation Changes Improve Coronavirus Disease 2019 Vaccine Immunity Without Decreasing the Risk for Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Due to early study closure, the study was not powered to evaluate COVID-19 frequency. Secondary analysis demonstrated that 12 months following vaccination, BCG increased coronavirus vaccine immunity compared to those who did not receive BCG. This increase in COVID-19 vaccine immunity correlated with BCG-induced DNA methylation changes.
Authors
- George Udeani (ORCID: https://orcid.org/0000-0001-5797-7849)
- Zoe Spieler
- Lynne A. Opperman (ORCID: https://orcid.org/0000-0002-6200-7799)
- Aaron B. Benjamin (ORCID: https://orcid.org/0000-0003-4387-2434)
- G. David Neal (ORCID: https://orcid.org/0000-0002-9441-6589)
- Pablo Avalos (ORCID: https://orcid.org/0000-0002-5313-5334)
- Theresa U. Ofili (ORCID: https://orcid.org/0000-0003-1392-0028)
- Jeffrey D. Cirillo (ORCID: https://orcid.org/0000-0003-3058-2702)
- Ashish M. Kamat (ORCID: https://orcid.org/0000-0003-3546-9928)
- Moshe Arditi (ORCID: https://orcid.org/0000-0001-9042-2909)
- Malik Ladki (ORCID: https://orcid.org/0000-0001-8735-5696)
- Anna M. Mandalakas (ORCID: https://orcid.org/0000-0002-8091-3509)
- Seth P. Lerner (ORCID: https://orcid.org/0000-0002-6379-2581)
- Cristian Coarfa (ORCID: https://orcid.org/0000-0002-4183-4939)
- Sandra L. Grimm (ORCID: https://orcid.org/0000-0002-0682-3134)
- Tajhal D. Patel
- Maxim Lebedev (ORCID: https://orcid.org/0000-0003-3188-1595)
- Santiago Carrero Longlax (ORCID: https://orcid.org/0000-0001-8731-0105)
- Andrew R. DiNardo (ORCID: https://orcid.org/0000-0001-5990-6470)
- Daanish Sheikh (ORCID: https://orcid.org/0000-0003-2216-034X)
- Kent J. Koster (ORCID: https://orcid.org/0000-0001-6256-8038)
- Tomoki Nishiguchi (ORCID: https://orcid.org/0000-0001-5549-7876)
- Abhimanyu Abhimanyu (ORCID: https://orcid.org/0000-0001-7888-8722)
- R. Hutchison (ORCID: https://orcid.org/0000-0002-0013-328X)
- Marisa Lozano
- Mihai G. Netea
- Alexandra Portillo
- Amrit Koirala (ORCID: https://orcid.org/0009-0008-6323-6041)
- Rebecca Hannigan
Institutions
- Texas A&M Health Science Center (US)
- Cedars-Sinai Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Radboud University Nijmegen (NL)
- Baylor College of Medicine (US)
- Texas College (US)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- International Craniofacial Institute (US)
- Texas A&M Health Science Center (US)
- German Center for Infection Research (DE)
- Research Center Borstel - Leibniz Lung Center (DE)
- Texas Children's Hospital (US)
- Texas A&M University (US)
- Bryan College (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1093/ofid/ofaf007
- Citations
- 3
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.72