The Inhibitory Effects of NCT503 and Exogenous Serine on High-Selenium Induced Insulin Resistance in Mice
The IR induced by high-Se intake in the body has been confirmed to be partially due to serine deficiency, which led to the initiation of SSP to produce endogenous serine. The supplementations of exogenous serine or inhibitors of PHGDH in this metabolic pathway could be used for the intervention.
Authors
- Mingyu Zhu (ORCID: https://orcid.org/0000-0002-2810-7286)
- Shuo Zhan
- Feng Han (ORCID: https://orcid.org/0000-0003-3561-4304)
- Jianrong Wang (ORCID: https://orcid.org/0000-0001-8180-5174)
- Licui Sun
- Yiqun Liu (ORCID: https://orcid.org/0000-0002-0543-0451)
- Qin Wang (ORCID: https://orcid.org/0000-0002-4955-1490)
- Zhenwu Huang (ORCID: https://orcid.org/0000-0002-6997-2612)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- National Health and Family Planning Commission (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2025-01-16
- DOI
- https://doi.org/10.3390/nu17020311
- Citations
- 4
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 4.48
Funders
- National Natural Science Foundation of China