Proteomic Profiling of the Large‐Vessel Vasculitis Spectrum Identifying Shared Signatures of Innate Immune Activation and Stromal Remodeling
These findings suggest shared pathobiology across the LVV spectrum involving innate immunity, lymphocyte homeostasis, and tissue remodeling. Network-based analyses highlighted immune-stromal cross-talk and identified novel therapeutic targets (eg, TNFSF14).
Authors
- Natalie Chaddock (ORCID: https://orcid.org/0000-0002-2256-5278)
- Justin C. Mason (ORCID: https://orcid.org/0000-0001-7783-1660)
- Marta Peverelli (ORCID: https://orcid.org/0000-0003-2856-2825)
- Andrew C.G. Porter (ORCID: https://orcid.org/0000-0002-6954-3041)
- Raashid Luqmani (ORCID: https://orcid.org/0000-0002-4446-5841)
- Ann W Morgan (ORCID: https://orcid.org/0000-0003-1109-624X)
- James Robinson (ORCID: https://orcid.org/0000-0001-5425-7520)
- James E. Peters (ORCID: https://orcid.org/0000-0002-9415-3440)
- Lubna Haroon‐Rashid
- Robert T. Maughan (ORCID: https://orcid.org/0000-0003-4153-903X)
- Erin Macdonald-Dunlop (ORCID: https://orcid.org/0000-0001-6569-6086)
- Taryn Youngstein (ORCID: https://orcid.org/0000-0002-8297-556X)
- Andrew Hutchings (ORCID: https://orcid.org/0000-0003-0215-9923)
- Charis Pericleous (ORCID: https://orcid.org/0000-0001-8804-0493)
- Louise Sørensen
- Shauna Masters
Institutions
- University of London (GB)
- University of Leeds (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Nuffield Orthopaedic Centre (GB)
- University of Oxford (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1002/art.43110
- Citations
- 2
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 3.04