Prostate cancer cells elevate glycolysis and G6PD in response to caffeic acid phenethyl ester-induced growth inhibition
Our study indicated that PCa cells attempted to overcome the CAPE-induced stress by upregulation of glycolysis and G6PD but failed to impede the growth inhibition caused by CAPE. Concurrent treatment of CAPE and inhibitors targeting glycolysis may be effective therapy for advanced PCa.
Authors
- Chieh Huo
- Tzyh‐Chyuan Hour (ORCID: https://orcid.org/0000-0001-8813-0704)
- Jen‐Kun Chen (ORCID: https://orcid.org/0000-0002-3433-5971)
- Chia‐Yang Li (ORCID: https://orcid.org/0000-0001-5689-9850)
- Jen-Chih Tseng
- Bi-Juan Wang
- Chien-Chih Yeh
- Chih‐Pin Chuu (ORCID: https://orcid.org/0000-0001-7206-7923)
- Li‐Jane Shih (ORCID: https://orcid.org/0000-0001-7195-7676)
- Pei‐Chun Chen (ORCID: https://orcid.org/0000-0002-2550-6556)
- Ching-Yu Lin
- Tzu-Ping Lin
- Ying-Yu Kuo
- Cheng-Li Kao
Institutions
- Tri-Service General Hospital (TW)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- National Chung Hsing University (TW)
- National Health Research Institutes (TW)
- China Medical University (TW)
- National Central University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Taoyuan Armed Forces General Hospital (TW)
- Taipei Medical University (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1186/s12885-025-13477-6
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology, Taiwan
- National Health Research Institutes
- National Science and Technology Council