The features of Tat protein of human immunodeficiency virus type 1 (Retroviridae: <i>Lentivirus: Lentivirus humimdef1</i>) non-A6 variants, characteristic for the Russian Federation
Consensus sequences of Tat protein in non-A6 variants typical for the Russian Federation were obtained and their features were determined. R78G, located in the functionally significant motif, and C31S, the functionally significant substitution, were significantly more frequent in subtype B variants circulating in Russia and in CRF63_02A6 variants than in the reference group, respectively. A limitation of this study is the small sample of sequences.
Authors
- Ilya Lapovok (ORCID: https://orcid.org/0000-0002-6328-1415)
- Anna Kuznetsovа (ORCID: https://orcid.org/0000-0001-5299-3081)
- Ekaterina Ozhmegova (ORCID: https://orcid.org/0000-0002-3110-0843)
- Oxana V. Galzitskaya (ORCID: https://orcid.org/0000-0002-3962-1520)
- Anastasiia Antonova (ORCID: https://orcid.org/0000-0002-9180-9846)
- Anastasia V. Shlykova (ORCID: https://orcid.org/0000-0002-1390-8021)
- Aleksey Lebedev (ORCID: https://orcid.org/0000-0001-6787-9345)
Institutions
- Institute of Theoretical and Experimental Biophysics (RU)
- Central Research Institute of Epidemiology (RU)
- Institute of Protein Research (RU)
- Institute of Virology of the Slovak Academy of Sciences (SK)
Publication Details
- Journal
- Problems of Virology
- Published
- 2024-12-15
- DOI
- https://doi.org/10.36233/0507-4088-272
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00