Garcinia Mangostana Pericarpium Extract: Representation of Vascular Adaptation Based on Circulating Cell Profile

Long exposure of cardiovascular risk factor were correlated with vascular aging due to interaction of oxidative stress or inflammation exposure leading alteration of vascular adaptation. Garcinia Mangostana Periparpium extract has been reported to display antioxidant effect and immunomodulatory properties. The current research was undertaken to explore the health benefit of Garcinia Mangostana Periparpium extract to vascular adaptation markers of subjects that presence of cardiovascular risk factor. A randomized double-blinded perspective control trial with pre-post design was conducted. The presence of cardiovascular risk factor calculate according Framingham Risk Score (FRS)10 years, each subject were treated with placebo or Garcinia Mangostana for 90 days. Peripheral blood of mononuclear cells (PBMNCs) was obtained from each participant before capsule consumption and one month after the latest capsule consumption. Circulating endothelial cells (CEC) and endothelial progenitor cells (EPCs) level was measured using Flowcytometry assay. The outcomes demonstrate that percentage of the number of CD146/CD45-positive cells/ CEC were significantly lower in treated group compared with the control group, meanwhile percentage of the number of CD133/CD34-positive cells/ EPC was significantly increased in treated group with Garcinia Mangostana Pericarpium. Our finding showed that administration of Garcinia Pericarpium Extract for 90 days could be beneficial for improving varcular adaptation of subject with cardiovascular risk factor based on circulating cell quantification.