Abstract 048: PPODA as a biocompatible coating for aneurysm treatment devices

Endovascular flow diverters (FDs) and stents, comprised of nitinol or cobalt alloys, have limited long‐term biocompatibility. These metals are associated with thromboembolic complications, leach genotoxic metal ions, and exhibit inconsistent reendothelialization at the aneurysm neck, resulting in delayed aneurysm occlusion. Although coated FDs and stents exist, there is insufficient data to support the reduction or elimination of periprocedural dual antiplatelet therapy (DAPT) when using these devices. Moreover, industry‐available coated FDs do not promote reliable endothelialization and aneurysm healing. There remains a need for further biocompatibility improvements using novel biomaterials and coating methods. PPODA‐QT is a biocompatible polymer under development for the treatment of intracranial aneurysms. ISO‐certified biocompatibility testing in canines demonstrated that PPODA‐QT has superior hemocompatibility, without the need for DAPT, and promotes complete endothelial growth over the aneurysm neck within 6‐months of treatment. This study has developed a process for coating nitinol wires with PPODA by adjusting various coating parameters, and assessed the mechanical stability of the coating.