Abstract 072: Antiplatelet Pre‐treatment and Outcomes of Mechanical Thrombectomy in Stroke Patients: A Meta‐analysis of 51,497 Patients

The efficacy of mechanical thrombectomy in large vessel occlusion has been well established, however, outcomes may be influenced by comorbid medical conditions and previously prescribed pharmacologic therapy. One such factor is prior antiplatelet therapy (APT), which is commonly used for secondary stroke prevention and managing other cardiovascular conditions. The interaction between prior APT and thrombectomy outcomes has been a subject of ongoing investigation. On one hand, prior APT may facilitate successful recanalization by potentially reducing clot burden or modifying clot characteristics. On the other hand, APT can increase the risk of bleeding complications, including symptomatic intracerebral hemorrhage (sICH), which is a serious adverse event that can significantly impact patient outcomes. This systematic review and meta‐analysis aimed to evaluate the association between prior APT and procedural and clinical outcomes in stroke patients undergoing mechanical thrombectomy.