Abstract 134: Recognizing Tirofiban Induced Thrombocytopenia After Acute Carotid Stenting in Mechanical Thrombectomy: A Case Report

Tirofiban, a glycoprotein IIb/IIIa receptor blocker, is commonly used in mechanical thrombectomy (MT) as an effective IV antiplatelet. A rare but significant side effect is severe thrombocytopenia, reported in 0.1%‐0.5% of clinical trials1. This reaction is thought to be caused by drug‐dependent antibodies binding to GP IIb/IIIa following conformational changes. While acute stenting for carotid stenosis is well established, data on this side effect remains limited2. We present a case of severe thrombocytopenia following second exposure to tirofiban in a patient undergoing mechanical thrombectomy and internal carotid artery stenting.