Abstract 374: Predictors of early intracerebral hemorrhage in patients with cerebral sinus venous thrombosis: Systematic review and meta‐analysis

Objectives Patients with cerebral venous thrombosis (CVT) may present with early intracerebral hemorrhage (EICH). The objective of this study was to identify predictors for EICH in CVT patients via a systematic review and meta‐analysis of observational studies. Methods Literature search on PubMed, EMBASE and Cochrane Library databases from inception up to 1 February 2024 was conducted. Five studies with predictors of EICH were included in qualitative synthesis and meta‐analysis. Results Pooled analysis demonstrated a statistically significant association between female gender and EICH (odd ratios (OR) = 1.51, 95% confidence interval (CI) = 1.23‐1.85, p < 0.01). The ICH patients had higher likelihood of seizures (OR = 3.07, 95% CI = 1.69‐5.58, p < 0.01), focal neurological deficits (OR = 4.07, 95% CI = 2.57‐6.44, p < 0.01), and decreased level of consciousness (OR=3.89, 95% CI = 2.53‐5.87, p < 0.01). Superior Sagittal Sinus thrombosis was associated with higher likelihood of EICH (OR: 1.49, 95% CI 1.05‐2.13, P = 0.03). No statistically significant association was demonstrated between presence of EICH and pregnancy, presence of hematological diseases or thrombophilia, or other site of venous thrombosis (deep venous system, or multiple sinuses involvement). Furthermore, patients who exhibited early EICH were notably less likely to attain a favorable functional outcome (mRS 0‐2) (OR: 0.28; 95% CI 0.16‐0.49; p < 0.001). Conclusion This meta‐analysis demonstrates that among CVT patients, female patients with new onset seizures, focal neurological deficits and decreased level of consciousness are more likely to present with EICH