Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos
The results of this study revealed that the characteristics of arsenic-induced methylome changes in F1 sperm are reproduced in both the paternal and maternal genomes of post-epigenetic reprogramming embryos. Furthermore, the results suggest that this re-establishment is achieved in collaboration with other factors that mediate region-specific methylation changes. These results also highlight the possibility that arsenic-induced sperm methylome changes could contribute to the development of disease predisposition in offspring.
Authors
- Keiko Nohara
- Kazuhiko Nakabayashi (ORCID: https://orcid.org/0000-0003-2927-0963)
- Tomoko Kawai (ORCID: https://orcid.org/0000-0001-8137-0334)
- Kazuyuki Okamura (ORCID: https://orcid.org/0000-0003-3882-9722)
- Takehiro Suzuki (ORCID: https://orcid.org/0000-0002-0585-6305)
Institutions
- National Institute for Environmental Studies (JP)
- National Center For Child Health and Development (JP)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-01-16
- DOI
- https://doi.org/10.1186/s13072-025-00569-7
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Center for Child Health and Development
- Ministry of Education, Culture, Sports, Science and Technology
- National Institute for Environmental Studies