Clinical and immunological characteristics of local immunity in patients with psoriasis

The results of the ELISA study of the proinflammatory cytokine TNF-α in patients with psoriasis revealed an increase in the level by 4.4 times and secretory IgA by 2.1 times compared with the indicators of control individuals (P<0.05). Correlation analysis of secreto ry immunoglobulin A and proinflammatory cytokine TNF-α indices revealed average significance of inverse correlation with secretory IgA — r=–0.3 (P<0.05). Whereas with the level of double-stranded AAT to IgG DS — r= –0.46 and DNA SS — r=- 0.5 had inverse correlation and were statistically significant. (P <0.05). Such picture was noted with indices of TNF-α with AAT as two — DS — r = — 0.4 and to single-stranded DNA — SS — r = — 0.36. The obtained data were statistically significant. In our opinion, increase in secretory IgA level is reflected in powerful stimulating effect of TNF-a, contributes to maintenance of aseptic inflammation in epidermis.