Evaluation of Antifungal and Antioxidant Activities and Determination of Total Phenolic Compounds of Ethanolic Extract from Juglans Regia Bark

Juglans regia (walnut tree) belongs to the Juglandaceae family and the Juglans genus, and is widely used in traditional medicine for its therapeutic effects. The purpose of the present work was to evaluate the in vitro antifungal and antioxidant activity of ethanolic extracts prepared from Juglans regia bark and to determine the total phenolic compounds of the prepared extracts. The results of the antifungal activity study showed that J. regia bark ethanolic extracts were active against the three tested Candida albicans yeast strains with interesting MICs values (0.039 mg/mL). For both extracts under study, the obtained results revealed appreciable antioxidant activity and a richness in total polyphenols with contents of 258 and 285 mg AGE/g of extract. The obtained data confirmed the correlation between the total phenolic compounds and biological activities of medicinal plant extracts. In addition, Juglans regia bark extracts demonstrate notable antifungal and antioxidant activities, which explains their use in traditional medicine and makes them suitable for use in pharmaceutical preparations.