<i>Message in a bubble</i>: Methods and uses of passive cavitation detection and passive acoustic mapping

An ever-growing body of clinical evidence demonstrates the profound impact of cavitation-based therapies on a wide variety of human pathologies. A key part of these evolving therapeutic techniques is the ability to detect, characterize, and quantify cavitation activity. In this session, we will describe the physical principles, devices, and algorithms for passive cavitation detection and mapping, with demonstrations and specific examples drawn from preclinical and clinical data. Finally, we will discuss the concept of cavitation dose and its distinct implementations for blood brain barrier opening, abdominal organ drug delivery, and histotripsy. The tutorial will include data and MATLAB code so that all attendees may play along.