Tumor Microenvironment Can Promote Cancer Cell Invasion and Foster Immune Suppression

Immunotherapy against tumors is an emerging field and it is gaining more attention. However, the efficiency of immunotherapy can be hindered by the complexity of the tumor microenvironment. In this paper, the mechanisms by which tumor microenvironment affects immune cells cytotoxicity and how it might suggest new treatment regimes were discussed. In addition, several new in vitro experiments were listed that point to new directions of supplementary treatments to enhance immunotherapy.