Planned Surgical Trajectory Affects Clinical Motor Outcome in Deep Brain Stimulation Targeted at Subthalamic Nucleus for Parkinson's Disease
Left DBS lead trajectory predicts adequate right-body motor outcome after bilateral STN-DBS. Greater planned trajectory angle relative to midsagittal plane reduces motor outcomes, independent of patients' ventricular width. These data may guide patient selection, inform risk/benefit discussions, optimize surgical planning, or support evidence-based evaluation of the methodologies used to select the approach trajectory, with careful consideration of the angle of approach relative to target.
Authors
- Joel S. Perlmutter (ORCID: https://orcid.org/0000-0003-3263-8917)
- Joshua L. Dowling (ORCID: https://orcid.org/0000-0002-0340-7493)
- Samer D. Tabbal
- Mwiza Ushe
- Mikhail Milchenko (ORCID: https://orcid.org/0000-0002-4022-1081)
- Laura S. Wang (ORCID: https://orcid.org/0000-0001-9883-5812)
- Scott A. Norris (ORCID: https://orcid.org/0000-0002-3835-0976)
- Isabel Alfradique‐Dunham (ORCID: https://orcid.org/0000-0002-7723-2956)
- John R. Younce (ORCID: https://orcid.org/0000-0003-4822-9608)
Institutions
- University of North Carolina at Chapel Hill (US)
- Washington University in St. Louis (US)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Operative Neurosurgery
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1227/ons.0000000000001355
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Parkinson Disease Association
- Foundation for Barnes-Jewish Hospital
- Paula and Rodger Riney Foundation
- National Institutes of Health