TRANSDERMALDRUGDELIVERY SYSTEM:NIOSOMESA MAGICAL MISSILE FOR NEOTERIC DRUG

In the past, the most affordable way of drugdelivery systemwas oral. Traditionaldosage forms such as capsules, pills, and tablets have been followed for ages, but they present various challenges such as intermittent dosing frequency, first-pass metabolism,poor absorption and bioavailability, poor patient compliance, and swallowing difficulties in geriatrics and pediatrics. To avoid these problems, an improved method of administering the drug to the body was introduced. TDDS aims to transport a drug molecule through the skin and has several advantages such as neglecting first-pass metabolism, delivery of the drug when oral administration is not appropriate, avoiding absorption of thedrug from the gastrointestinaltract, and ease of use and removal. Transdermaldrug delivery isaskin barrier provided by itsouter layer beforeitreachesthesystemiccirculation. This review covers new drug carriers, such as niosomes, which can effectively encapsulate various drugs and can be used in transdermal drug delivery systems to improve drug specificity and help overcome the drug's barrier function for better absorption through the skin