<i>CYP2C19</i> and <i>CES1</i> gene variants affecting clopidogrel metabolism in a South Asian population from Sri Lanka
Given that South Asians share genetic similarities, these findings suggest that a substantial proportion of the region's population may also be poor responders to clopidogrel, increasing the risk of adverse outcomes. This highlights the importance of genotype-guided antiplatelet therapy, which could improve clinical outcomes across South Asia amidst rising cardiovascular disease rates.
Authors
- Nirmala D. Sirisena (ORCID: https://orcid.org/0000-0003-0994-6954)
- Vajira H. W. Dissanayake (ORCID: https://orcid.org/0000-0002-3264-6856)
- Priyanga Ranasinghe (ORCID: https://orcid.org/0000-0002-1522-9276)
- D. P. Bhagya Hendalage (ORCID: https://orcid.org/0009-0006-6228-6333)
- Hajanthy Jeyapragasam (ORCID: https://orcid.org/0009-0002-0802-4712)
- Pulasthi B. Gunarathna
Institutions
- University of Colombo (LK)
Publication Details
- Journal
- Pharmacogenomics
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1080/14622416.2025.2452835
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00