Portable Multifunctional Urine Analysis System for Early Diagnosis of Kidney Disease

This study presents a portable urine analysis system designed for the accurate measurement of the urine albumin-to-creatinine ratio, crucial for diagnosing kidney disease. The system employs both a europium(III)-based strip for microalbumin detection and a colorimetric strip for creatinine detection, addressing the distinct analytical needs of these biomarkers. Utilizing a CMOS-based sensor, the system captures high-resolution fluorescence and visible light images, with UV and white LEDs providing even illumination. This setup ensures reliable, rapid, and non-invasive testing, making it suitable for point-of-care applications in diverse clinical environments. Validation with buffer solutions demonstrated a strong correlation between the fluorescence intensity and microalbumin concentration (5–300 mg/L), as well as between the color intensity and creatinine concentration (1–300 mg/dL), both achieving an R<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup>value of over 0.99. The portable urine analysis system thus offers a robust and cost-effective tool for early detection and monitoring of kidney disease, enhancing clinical outcomes through timely diagnosis and management.