Design and Characterization of bimodal Release Formulation of Valsartan and Metformin hydrochloride

A cardiovascular diseaseis mainlyreason for one third of global deaths and which is a leading and increasing contributor to the global disease burden. Hypertension is another risk factor for heart disease and is the single most risk factor for stroke. Patients with diabetes are 2-4 times more likely suffering and/or die of coronary heart disease. The aim of the research investigation is to design and characterization of bilayer tablets for bimodal drug release. Valsartan is selected as a drug of choice for immediate release layer preparation and for sustained release layer preparation metformin hydrochloride was selected. Bilayer tablets were prepared by double compression procedure. Immediate release tablets are prepared by physical mixing procedure to improve the drug solubility. All the tablets were characterized by Differential scanning calorimetry, Fourier transform infrared, X-Ray diffraction, Scanning electron microscopy. Among the three immediate release formulations IF2 containing 4% sodium starch glycolate shows 84.46% drug release in 30 mins and 99.69% drug release in 1hr. Among all the six sustained release formulations SF3 shows 99.76±0.9% drug release for an extended period up to 12hrs. Both optimized layers were considered to formulate bilayer tablets by direct compression technique. From the results it was concluded that combination dosage form can be achieved by bilayer tablet, the prepared bilayer tablet containing 4% SSG shows immediate action with improved oral bioavailability from IR layer and 16% hydroxy propyl methyl cellulose K100 shows drug release for prolonged period of time with improved bioavailability.