PREPARATION, CHARACTERIZATION and DRUG RELEASE BEHAVIOR OF A CLINOPTIOLITE INCORPORATED POLYACRYLAMIDE GRAFTED GELATIN NANOCOMPOSITE IN SITU HYDROGEL

In this study, the novel gelatin based in situ hydrogel nanocomposites were prepared from incorporating clinoptiolite (CL) and Lidocaine (LD) as a model local anesthetic drug within polyacrylamide-g-gelatin (PA-g-GA) hydrogel during the synthesis by free radical polymerization. The prepared PA-g-GA, PA-g-GA/CL and drug loaded PA-g-GA/CL in situ hydrogel nanocomposites were analyzed by FTIR and SEM. The drug release behavior of the synthesized composite hydrogel was investigated with UV-Vis spectrophotometry. Swelling and drug release behavior of the new prepared hydrogel nanocomposites were investigated with different CL and drug content in the gel structure. FTIR and SEM analysis revealed that the LD loaded PA-g-GA/CL nanocomposite was successfully prepared. Drug release (%) decreased when the drug loading and CL amount in the composite increased. Various kinetic models for all drug release data were applied in order to study drug release behavior. Korsmeyer-Peppas model fitted for the drug release data of all samples. Swelling, drug release properties of the new nanocomposites were improved with the incorporation of clinoptiolite in the gel structure.