<i>UPF1</i> Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating <i>SMURF2</i>-Mediated Ubiquitination Degradation of <i>FOXA2</i>

By suppressing SMURF2 mRNA stability, UPF1 upregulated FOXA2 expression to inhibit PAR4, leading to inhibition of apoptosis during MIRI, which provides new therapeutic targets for MIRI treatment.

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Publication Details

Journal
Korean Circulation Journal
Published
2025-01-01
DOI
https://doi.org/10.4070/kcj.2024.0190
Citations
4
Primary Topic
Cardiovascular Function and Risk Factors
Type
article
Field-Weighted Citation Impact
5.55
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article

UPF1 Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating SMURF2-Mediated Ubiquitination Degradation of FOXA2

K. Chen, Aixin Li, Peng Li, Dong Li et al.
4 citations
Korean Circulation Journal
Cardiovascular Function and Risk Factors
5.55
article

UPF1 Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating SMURF2-Mediated Ubiquitination Degradation of FOXA2

K. Chen, Aixin Li, Peng Li, Dong Li, Chunling Mu, Zhaoguang Liang
article en
4 citations

Abstract

By suppressing SMURF2 mRNA stability, UPF1 upregulated FOXA2 expression to inhibit PAR4, leading to inhibition of apoptosis during MIRI, which provides new therapeutic targets for MIRI treatment.

Korean Circulation JournalVol. 55(4)
Jiamusi University (CN), Harbin Medical University (CN), First Affiliated Hospital of Jiamusi University (CN), Fourth Affiliated Hospital of Harbin Medical University (CN), First Affiliated Hospital of Harbin Medical University (CN)
Zero hunger
Openalex Percentile: Top 5%
Cardiovascular Function and Risk Factors
5.55
DOIOpen Access PDFOpenAlex
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