Impact of sex hormones on pheochromocytomas, paragangliomas, and gastroenteropancreatic neuroendocrine tumors
We provide novel data on the effects of elevated sex hormone levels, potentially seen during pregnancy or hormone replacement therapy, on PPGL/GEP-NET tumor growth. G-1 might offer a novel therapeutic approach for some PPGLs depending on patient's sex and the individual tumor's genetic/molecular background. All HNPGLs showed ERα positivity.
Authors
- Natalia S. Pellegata (ORCID: https://orcid.org/0000-0002-8000-7784)
- Umberto Macciò (ORCID: https://orcid.org/0000-0003-3253-3787)
- Felix Beuschlein (ORCID: https://orcid.org/0000-0001-7826-3984)
- Martin Faßnacht (ORCID: https://orcid.org/0000-0001-6170-6398)
- Martín Reincke (ORCID: https://orcid.org/0000-0002-9817-9875)
- Christoph Josef Auernhammer (ORCID: https://orcid.org/0000-0001-8087-3722)
- Alessa Fischer (ORCID: https://orcid.org/0000-0003-4555-8334)
- Hermine Mohr (ORCID: https://orcid.org/0000-0002-3061-1166)
- Matthias Kroiß (ORCID: https://orcid.org/0000-0002-7628-3161)
- Zsolt Kulcsár (ORCID: https://orcid.org/0000-0002-6805-5150)
- Alexander Huber (ORCID: https://orcid.org/0000-0002-8888-8483)
- Hanno Nieß (ORCID: https://orcid.org/0000-0002-0981-4049)
- Constanze Hantel (ORCID: https://orcid.org/0009-0000-8906-2563)
- Nicole Bechmann (ORCID: https://orcid.org/0000-0002-6932-333X)
- Grégoire B. Morand (ORCID: https://orcid.org/0000-0002-6150-6772)
- Diana Vetter (ORCID: https://orcid.org/0000-0001-9622-0988)
- Matthias Ilmer (ORCID: https://orcid.org/0000-0001-9597-1368)
- Katharina Wang (ORCID: https://orcid.org/0000-0002-7795-1395)
- Mercedes Robledo (ORCID: https://orcid.org/0000-0001-6256-5902)
- Petra Zimmermann (ORCID: https://orcid.org/0000-0002-2388-4318)
- Karel Pacák (ORCID: https://orcid.org/0000-0002-3541-3767)
- Michael Lauseker (ORCID: https://orcid.org/0000-0002-6662-7127)
- Thomas Knösel (ORCID: https://orcid.org/0000-0002-1822-0197)
- Simon Gahr
- Svenja Nölting (ORCID: https://orcid.org/0000-0002-7064-590X)
- Astrid Reul
- Katharina Schilbach (ORCID: https://orcid.org/0000-0002-8667-0296)
- Kuno Lehmann (ORCID: https://orcid.org/0000-0002-6177-9543)
- Lea Peischer
- Simon Müller
- Kathrin Zitzmann (ORCID: https://orcid.org/0009-0001-2341-3161)
- Julian Maurer
- Jana Bauer
Institutions
- Zimmer Biomet (Netherlands) (NL)
- University of Zurich (CH)
- University of Pavia (IT)
- The Royal Free Hospital (GB)
- LMU Klinikum (DE)
- University of Oxford (GB)
- European Neuroendocrine Tumor Society (DE)
- Spanish National Cancer Research Centre (ES)
- University Hospital of Zurich (CH)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro de Investigación Biomédica en Red (ES)
- Universitätsklinikum Würzburg (DE)
- Cancer Research Center (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- German Center for Diabetes Research (DE)
- University Hospital Carl Gustav Carus (DE)
- University College London (GB)
- Technische Universität Dresden (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/ejendo/lvae163
- Citations
- 3
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Deutsche Forschungsgemeinschaft