D-Loop Region Variability in Ovarian Cancer Among Senegalese Patients

Our study aimed to determine the genetic variability of the D-loop region in a Senegalese population with ovarian cancer. This research involved healthy and cancerous tissue samples obtained from Senegalese women diagnosed with ovarian cancer. Extraction of mtDNA from the D-loop region, followed by sequencing, yielded 49 nucleotide sequences. These sequences will be utilized to investigate several parameters of genetic variability: allelic frequencies, nucleotide frequencies, and mutation rates. Additionally, we will explore intra- and inter-individual diversity, assess genetic variability between different tissue types from distinct individuals, and illustrate both intra- and inter-individual haplotypic diversity.