UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research
Givinostat was rapidly absorbed and cleared slowly in vivo, and it was confirmed by in vitro experiments. This study provides a potential reference for givinostat in clinical studies.
Authors
- Ruanjuan Zhan (ORCID: https://orcid.org/0000-0002-5046-9806)
- Xiaocheng Chen
- Yanan Liu (ORCID: https://orcid.org/0000-0002-6327-344X)
- Yuxin Shen (ORCID: https://orcid.org/0009-0004-1742-0797)
- Jun Wu (ORCID: https://orcid.org/0000-0002-6785-6976)
- Xinhao Xu (ORCID: https://orcid.org/0009-0008-6326-4552)
- Guanyang Lin
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/dddt.s497308
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00