A sequential Au(<scp>i</scp>)/TBAF-promoted rapid and selective functionalization of heteroarene <i>N</i>-oxides with alkynes
We present a rapid and versatile Au(I)-catalyzed strategy for functionalizing N-heteroarenes using TBAF as a nucleophile or base, enabling varied transformations. The method accommodates diverse substrates, offering excellent yields and functional group tolerance. Distinct reaction pathways highlight its adaptability, expanding chemical diversity for organic synthesis.
Authors
- Heping Shi (ORCID: https://orcid.org/0000-0003-2937-480X)
- Dan Luo (ORCID: https://orcid.org/0000-0001-7572-3885)
- Nan Wu (ORCID: https://orcid.org/0000-0002-9429-2889)
- Lei Huang (ORCID: https://orcid.org/0000-0003-2110-2949)
- Mengfei Jiang
- Zhou Xu (ORCID: https://orcid.org/0000-0002-9703-8245)
- Huilong Zhu (ORCID: https://orcid.org/0000-0003-1831-7359)
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4cc06305h
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China