Synthesis of indole-fused benzodiazepine derivatives by photocatalyzed cascade reaction
We report a cascade synthesis of indole-fused benzodiazepines by the photocatalyzed addition of phenacyl radical, generated from α-acetoxy acetophenone, to 2-(3-methyl-1<i>H</i>-indol-1-yl)aniline, and subsequent cyclodehydration. A range of indole-fused benzodiazepines were obtained from readily available substrates.
Authors
- Tatsuhiro Uchikura (ORCID: https://orcid.org/0000-0002-0327-3675)
- Tatsushi Oishi (ORCID: https://orcid.org/0009-0009-0151-1295)
- Takahiko Akiyama (ORCID: https://orcid.org/0000-0003-4709-4107)
Institutions
- Gakushuin University (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4cc05755d
- Citations
- 5
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Japan Society for the Promotion of Science