Formulation and Characterization of PLGA-quercetin Hybrid Material with Pharmaceutical Applications

A new bicomponent hybrid material was obtained by encapsulating quercetin in PLGA using solvent evaporation method. The morphological aspects of the samples were established by scanning electron microscopy (SEM). Particle size distribution was determined by dynamic light scattering (DLS), numerical distribution showing that the particles are micrometric, with two granulometric intervals: [385-479] nm and [662-918] nm. Morphology was typical for PLGA, spherical one; the obtained particles are porous with micrometric pores. Zeta potential (ZP, -4.84mV) showed that the particles have electronegative surface charge. The loading efficiency was determined spectrophotometric and it was 18.3% in the mentioned synthesis conditions.