Prediction Of Non-Invasive Ventilation Failure Using The Ratio Of Oxygen Saturation Index In Type 1 Respiratory Failure Patients

This study investigated the predictive capability of the ratio of oxygen saturation (ROX) index in determining non-invasive ventilation (NIV) failure among patients with type 1 respiratory failure. Conducted as a prospective observational study in the ICU, the research included patients who met strict inclusion criteria, with outcomes grouped by NIV success or failure. Key measures such as the ROX index and HACOR score (Heart Rate, Acidosis, Consciousness, Oxygenation and Respiratory Rate) were assessed at various intervals (1, 12, and 24 hours after NIV initiation) to determine predictive performance. The results showed that an early ROX index cutoff value of 2 was highly sensitive in predicting NIV failure within the initial hours. A comparison between the ROX index and the HACOR score revealed similar predictive abilities, with the HACOR score slightly outperforming the ROX index at the 6-hour time point, although this difference diminished at later intervals. These findings underscore the utility of the ROX index as an accessible, non-invasive tool for the prediction of early NIV failure, with implications for timely interventions in critical-care settings. Further research in diverse clinical environments is recommended to validate and expand upon these findings