Anti Inflammation Effectivity Gel Formulated From Ethanol Extract of Ketepeng Cina Leaves (Cassia alata L.) Leaves

ABSTRACT Metabolites including flavonoids, tannins, saponins, alkaloids, terpenoids, anthraquinones, phenolics, glucose, and phytosterols are present in the Ketepeng Cina (Cassia alata L.) plant. When physical stress causes tissue injury, inflammation is the body's natural defensive reaction. This research aim to formulate gel preparation from ethanol extract of ketepeng cina leaves and determine its antiinflammatory activity on carrageenan induced mice (Mus musculus). This is experimental research, including collection of materials and prociessing of materials, making simplisia, making ethanol extract with a concentration of 5%, 10% and 15%, making ethanol extract gel of Ketepeng Cina leaves and testing the anti-inflammatory effect on mice. The results showed that the ethanol extract can be formulated in the form of gel dosage form with concentrations of 5%, 10% and 15% and has a qualified quality preparation evaluation. The observation results showed that the percentage of Inflammation Inhibition at the 5th hour on the gel with a concentration of 15% was 100%. Statistical Analysis of One Way Anova the percentage of inflammation at the 5th hour to the 6th hour showed a significant difference. So it can be stated that the preparation of ethanol extract gel of Ketepeng Cina leaves has the best anti-inflammatory effect at a concentration of 15%.