The prospect of overcoming antibiotic resistance using plant agro-wastes – systematic review

The article summarizes the latest data on the possibilities of using agricultural waste for the development of effective means of combating microorganisms. A comprehensive search was carried out using PubMed, Google Scholar, and Scopus databases. The methods of preparation of solutions from raw plant materials are detailed, and their biochemical composition is given. Microorganisms that have aroused the scientific and practical interest of researchers from different countries of the world are also indicated. For ease of understanding, the primary material indicating the sensitivity of microorganisms to plant extracts is presented in the form of a table. It should be noted that the concept of “agro-waste” is different in different countries, but everywhere it is planted, raw material is not subject to further processing, human consumption, or animal feeding. Since such raw materials are abundant and cheap, they should be considered as a potential source of biochemically active substances for use in various spheres of human life. Natural biochemical substances are of indisputable importance in the fight against microorganisms – pathogens of humans (animals), which, through specific mutational mechanisms, have developed resistance to widely used antimicrobial agents. Resistant strains are potentially dangerous biologically and “economically” due to the difficulty of fighting them and attracting significant financial resources to this fight. The current situation prompts scientists to search for cheap, easy-to-prepare (use) and effective means. Based on the materials of the article, raw materials of plant origin – agricultural waste – have the potential to overcome the problem of antibiotic resistance, but further, more in-depth study of their properties is required.