Comparison of the efficacy and safety of Landiolol and Esmolol in critically ill patients: a propensity score-matched study
Landiolol provides superior heart rate control in critically ill patients with tachycardia compared to Esmolol, without increasing vasopressor requirements during the first 24 h. Findings from ScvO<sub>2</sub> levels and PCO<sub>2</sub> gap suggest that Landiolol may exert less impact on cardiac output than Esmolol. Further studies, incorporating comprehensive hemodynamic monitoring, are warranted to clarify the clinical implications of heart rate control with β-blockers in ICU patients with tachycardia.
Authors
- Minying Chen (ORCID: https://orcid.org/0000-0001-7646-1311)
- Xiaosheng Ma (ORCID: https://orcid.org/0000-0003-3690-0513)
- Tao Yang (ORCID: https://orcid.org/0000-0003-4101-2385)
- Yuan Hao (ORCID: https://orcid.org/0000-0003-2322-6806)
- Wenliang Song (ORCID: https://orcid.org/0000-0003-0138-1776)
- Jiayan Guo
- Xavier Monnet (ORCID: https://orcid.org/0000-0001-6820-2678)
- Huiming Wang (ORCID: https://orcid.org/0000-0002-1706-2342)
- Xiang Si (ORCID: https://orcid.org/0009-0002-3856-2693)
- Jinlong Jiang (ORCID: https://orcid.org/0000-0002-4889-9292)
- Jianfeng Wu (ORCID: https://orcid.org/0000-0001-9098-2500)
- Xiangdong Guan (ORCID: https://orcid.org/0000-0002-5050-0359)
- Rui Shi (ORCID: https://orcid.org/0000-0001-7400-9962)
Institutions
- Inserm (FR)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Université Paris-Saclay (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Bicêtre Hospital (FR)
Publication Details
- Journal
- Annals of Intensive Care
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1186/s13613-024-01418-8
- Citations
- 5
- Primary Topic
- Hemodynamic Monitoring and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- Guangdong Medical Research Foundation
- Wu Jieping Medical Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province