Preliminary Evidence for Perturbation‐Based tACS‐EEG Biomarkers of Gamma Activity in Alzheimer's Disease
Our work suggests a link between tACS-induced γ band spectral power and clinical severity, with weaker γ induction corresponding to more severe clinical/cognitive impairment. This study provides preliminary support for the development of novel physiological biomarkers and therapeutic targets based on disease severity.
Authors
- Davide Rivolta (ORCID: https://orcid.org/0000-0002-9969-9135)
- Emiliano Santarnecchi (ORCID: https://orcid.org/0000-0002-6533-7427)
- Davide Cappon (ORCID: https://orcid.org/0000-0002-0326-2191)
- Annalisa Palmisano (ORCID: https://orcid.org/0000-0003-4193-534X)
- Giulio Ruffini (ORCID: https://orcid.org/0000-0003-3084-0177)
- Álvaro Pascual‐Leone (ORCID: https://orcid.org/0000-0001-8975-0382)
- Sara M. Romanella (ORCID: https://orcid.org/0000-0002-7202-5421)
- Giacomo Koch (ORCID: https://orcid.org/0000-0001-6155-9439)
- Elisa Tatti (ORCID: https://orcid.org/0000-0002-7137-550X)
- Carmelo Luca Smeralda (ORCID: https://orcid.org/0000-0001-5331-9400)
- Joanna Macone
- Luke R. Pezanko
- Daniel Z. Press (ORCID: https://orcid.org/0000-0001-6401-1305)
- Georges El‐Fakhri
Institutions
- University of Siena (IT)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- CUNY School of Law (US)
- Yale University (US)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Light Prescriptions Innovators (Spain) (ES)
- Hebrew SeniorLife (US)
- Berenson Allen Center for Noninvasive Brain Stimulation (US)
- Fondazione Santa Lucia (IT)
- University of Bari Aldo Moro (IT)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- International Journal of Geriatric Psychiatry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/gps.70025
- Citations
- 2
- Primary Topic
- EEG and Brain-Computer Interfaces
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Alzheimer's Drug Discovery Foundation
- Association for Frontotemporal Degeneration
- National Institutes of Health
- European Research Council