CMPK2 promotes NLRP3 inflammasome activation via mtDNA‐STING pathway in house dust mite‐induced allergic rhinitis
Cytidine/uridine monophosphate kinase 2 (CMPK2) expression is up-regulated in the nasal mucosa of patients and mice with allergic rhinitis (AR). CMPK2 caused NLRP3 inflammasome activation via mitochondrial DNA (mtDNA)-STING pathway. Blocking CMPK2 or STING signalling significantly reduced the activation of NLRP3 in house dust mite (HDM)-challenged mice and human nasal epithelial cells (HNEPCs).
Authors
- Yaoming Zheng (ORCID: https://orcid.org/0000-0001-5267-3707)
- Hongfei Lou (ORCID: https://orcid.org/0000-0002-8553-812X)
- Hua‐Bin Li (ORCID: https://orcid.org/0000-0003-2332-8554)
- Hui Xiao (ORCID: https://orcid.org/0000-0001-5304-243X)
- Yujie Cao (ORCID: https://orcid.org/0000-0002-1014-6578)
- Yilai Shu (ORCID: https://orcid.org/0000-0001-8893-434X)
- Jiaying Li (ORCID: https://orcid.org/0000-0001-7508-1579)
- Qing Cao (ORCID: https://orcid.org/0000-0001-6276-5007)
- Miaomiao Han (ORCID: https://orcid.org/0000-0002-6941-5816)
- Y. Xie (ORCID: https://orcid.org/0000-0001-5012-4069)
- Min Li (ORCID: https://orcid.org/0000-0001-8786-5629)
Institutions
- Eye & ENT Hospital of Fudan University (CN)
- Center for Excellence in Molecular Cell Science (CN)
- University of Chinese Academy of Sciences (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/ctm2.70180
- Citations
- 14
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 11.28
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China