Non‐differential gut microbes contribute to hypertension and its severity through co‐abundances: A multi‐regional prospective cohort study
Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research has primarily focused on differential abundances, our study highlights the role of non-differential microbes in hypertension. We propose that non-differential microbes contribute to hypertension through their ecological interactions, as defined by co-abundances (pairs of microbes exhibiting correlated abundance patterns). Using gut microbiome data from the Guangdong Gut Microbiome Project, which includes 2355 hypertensive and 4644 non-hypertensive participants across 14 regions, we identified replicable hypertension-related microbial interactions. Notably, most co-abundances involved non-differential microbes, which were found to correlate with both hypertension severity and hypertension-related microbial metabolic pathways. These findings emphasize the importance of microbial interactions in hypertension pathogenesis and propose a novel perspective for microbiome-based therapeutic strategies.
Authors
- Xiangqing Kong (ORCID: https://orcid.org/0000-0001-8245-867X)
- Qiufeng Deng
- Yuwen Jiao (ORCID: https://orcid.org/0000-0001-9417-4279)
- Liming Tang (ORCID: https://orcid.org/0000-0002-3730-3131)
- Shixian Hu (ORCID: https://orcid.org/0000-0002-1190-0325)
- Huayiyang Zou
- Jingxiang Fu (ORCID: https://orcid.org/0000-0003-3009-5269)
- Yuhao Sun (ORCID: https://orcid.org/0000-0001-6987-3721)
- Wei Sun (ORCID: https://orcid.org/0000-0002-7366-1462)
- Yan He (ORCID: https://orcid.org/0000-0002-6611-2959)
- Hongwei Zhou (ORCID: https://orcid.org/0000-0002-9478-4023)
- Lianmin Chen (ORCID: https://orcid.org/0000-0003-0660-3518)
- Wenjun Ma (ORCID: https://orcid.org/0000-0002-9266-4802)
- Beining Ma
- Muxuan Chen (ORCID: https://orcid.org/0000-0002-8961-2649)
- Chao Zheng (ORCID: https://orcid.org/0009-0001-7226-2355)
- Yifeng Wang (ORCID: https://orcid.org/0000-0002-1815-3991)
- Tingting Wu (ORCID: https://orcid.org/0000-0003-3437-8899)
- Yan Zhou
- Wei Wu (ORCID: https://orcid.org/0000-0003-3097-2399)
- Jing Shi (ORCID: https://orcid.org/0000-0002-2100-6888)
- Xiaojiao Chen (ORCID: https://orcid.org/0000-0003-3954-9570)
- Yanhui Sheng (ORCID: https://orcid.org/0000-0001-5109-8704)
- Zhenchao Ma
- Quanbin Dong (ORCID: https://orcid.org/0000-0002-0849-8136)
- Tianbao Xu
- Lu Liu (ORCID: https://orcid.org/0009-0008-7393-4329)
- Qianyi Zhou
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Huzhou Central Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Zhujiang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Changzhou No.2 People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Southern Medical University (CN)
- Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- iMeta
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1002/imt2.268
- Citations
- 16
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 12.90
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing Medical University
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Young Scientists Fund