Impact of Nutritional Factors on Colorectal Cancer: Implication the molecular mechanisms of Vitamins Supplementation

Colorectal cancer (CRC) is the leading cause of death from gastrointestinal cancer, the second largest cause of cancer-related death worldwide, and the third most common cancer in both men and women. Bad eating habits, smoking, intestinal inflammatory diseases, polyps, aging, and genetic factors all increase the risk of developing colorectal cancer. More interestingly, vitamin deficiency has been associated with an increased risk of colorectal cancer. We reviewed the published significance of vitamin supplementation on colorectal cancer proliferation, survival, apoptosis, angiogenesis and migration, focusing on the possible molecular mechanisms of water-soluble and fat-soluble vitamins to provide protective suggestions to minimize the occurrence and progression of colorectal cancer.