Porphyrin-graphdiyne analogue modified MXene nanosheets for highly efficient, stable and long-term antibacterials

MXene, a widely utilized two-dimensional (2D) nanomaterial, demonstrates superior surface area and exceptional photothermal properties, making it a promising candidate for antibacterial applications. In this study, we synthesized a Zn (II) porphyrin-based graphdiyne analog (PDY) on the surface of MXene, namely PDY-MXene, via an in-situ growth method by using Zn (II) 5, 10, 15, 20-(tetra(4-(trimethylsilyl)ethynylphenyl)porphyrin (Zn-TTPP) as a monomer. The novel PDY-MXene nanocomposite exhibited comparable antibacterial efficacy to pure MXene while enhancing its long-term stability. The photothermal conversion efficiency of PDY-MXene was calculated to be 43.07 %. Under NIR irradiation (2 W·cm −2 , 808 nm) for 6 min, PDY-MXene after 7-day immersion in water still achieved a bacterial reduction of 99.8 % against E. coli and 99.5 % against S. aureus at a concentration of only 60 μg·mL −1 . It indicated that the incorporation of PDY maintained the antibacterial properties of MXene resulting from the improved oxidation resistance of PDY-MXene. More importantly, the biocompatibility of PDY-MXene was excellent (cell viability > 84 %), enabling PDY-MXene a potential candidate for highly efficient and long-term antibacterial applications. • Zn (II) porphyrin-based graphdiyne analog (PDY) was successfully synthesized. • MXene modified with PDY was prepared via an in-situ growth method. • PDY-MXene exhibited efficient and long-term antibacterial performance. • PDY-MXene showed good biocompatibility.