A CLINICAL CASE OF ACROMEGALY WITH NORMAL GH AND ELEVATED INSULIN-LIKE GROWTH FACTOR – 1 LEVELS

Abstract. Introduction. Prevalence of acromegaly is 4.6 cases per 1 million people, and the incidence is 116.9 new cases per 1 million annually. At the same time, the manifestations of acromegaly can be insidious, and despite advances in this area, there are significant delays in the diagnosis of the disease, thereby worsening the prognosis for patients. Aim. To study the features of laboratory diagnostics of acromegaly. Materials and Methods. This article presents a clinical case of a 56-year-old female patient with discordant values: Elevated insulin-like growth factor-1 and normal somatotropic hormone levels. Results and Discussion. Levels of somatotropic hormone and insulin-like growth factor-1 are closely correlated. However, up to 30% of patients have discrepancies in these indicators. The most common variant is a combination of elevated insulin-like growth factor-1 levels with normal growth hormone levels, which most likely reflects the onset of a pathological process or a milder form of the disease. Conclusions. In connection with the findings obtained in this clinical case, attention should be paid to the importance of a comprehensive approach to examining patients for acromegaly, using all available laboratory techniques, along with anamnesis, clinical features, and imaging studies.