FEATURES OF ISCHEMIC STROKE IN PRESENCE OF VASCULOPATHY AND COMPENSATION ABILITIES OF THE BRAIN: A CLINICAL CASE

Abstract. Introduction. Vasculopathies are inflammations of the walls of blood vessels, in which immunopathological processes cause endothelial dysfunction of the vessels. Changes in endothelial dysfunction are a universal pathogenetic mechanism for the development of ischemic circulatory disorders. Given the permanent development of ideas about immunopathological disorders, situations may arise with the need for revising the features of the cause of acute circulatory disorders in a particular case. Aim. To demonstrate the features of ischemic stroke in presence of vasculopathy and the compensatory capabilities of the brain. Materials and methods. A clinical case of female patient F., 77 years old, with vasculitis-associated ischemic stroke is presented. Results and Discussion. In vasculitis, the vascular walls are attacked by the body’s immune system, which leads to structural disorders. Short-term exposure of the vascular wall endothelium to the pathological factor leads to hypercoagulation, hypertonus, and production of inflammatory cytokines. It has been proven that endothelial activation is a favorable reaction that promotes an immune response to the pathogen. Cessation of the pathogenic stimulus leads to a rapid return of the endothelium from the activated state to the physiological one Accordingly, the course of ischemic stroke in immunopathological disorders may be atypical and, therefore, additional diagnostic methods and therapy correction are needed, taking into account the pathogenetic factor, considering the mechanisms of brain plasticity. Conclusions. The increasing frequency of autoimmune diseases necessitates a deeper understanding of the mechanisms, diagnostics and treatment of acute cerebrovascular accidents. Ischemic stroke with some existing brain processes develops with latent symptoms, which indicates the great compensation abilities of the brain, which can be a theoretical basis for neurorehabilitation.