Utilization of primary tumor samples for cancer neoantigen discovery
Our findings indicate that primary FFPE tumor-derived screening libraries could be used to discover most neoantigens present in metastatic tumors requiring treatment. Furthermore, this approach can reveal additional neoantigens not present in resected metastatic tumors, prompting further research to understand their clinical relevance as potential therapeutic targets.
Authors
- Jared J. Gartner (ORCID: https://orcid.org/0000-0003-2924-3519)
- Noam Levin (ORCID: https://orcid.org/0000-0003-0664-2808)
- Vid Leko (ORCID: https://orcid.org/0000-0001-7883-5030)
- Sivasish Sindiri (ORCID: https://orcid.org/0000-0003-2516-969X)
- Devikala Gurusamy (ORCID: https://orcid.org/0000-0002-1727-8653)
- Amy R. Copeland (ORCID: https://orcid.org/0000-0002-2916-4098)
- Sanghyun P. Kim (ORCID: https://orcid.org/0000-0001-9519-1994)
- Billel Gasmi (ORCID: https://orcid.org/0000-0002-8061-8278)
- Paul F. Robbins (ORCID: https://orcid.org/0000-0002-1260-8123)
- Victoria Hill (ORCID: https://orcid.org/0000-0003-2214-2459)
- Bradley Sinclair White
- Frank J. Lowery (ORCID: https://orcid.org/0000-0002-4620-5293)
- Shoshana T. Levi (ORCID: https://orcid.org/0000-0001-9146-4000)
- Steven A. Rosenberg (ORCID: https://orcid.org/0000-0002-8939-8910)
- Todd D. Prickett (ORCID: https://orcid.org/0000-0001-5466-4150)
- Stephanie L. Goff (ORCID: https://orcid.org/0000-0003-3317-9804)
- Eric Groh
- Maria Parkhust
- Yong Li (ORCID: https://orcid.org/0000-0001-8838-1714)
Institutions
- National Cancer Institute (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/jitc-2024-010993
- Citations
- 4
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- National Cancer Institute