Early assessment of IL8 and PD1+ Treg predicts response and guides treatment monitoring in cemiplimab-treated cutaneous squamous cell carcinoma
Taken together, these findings shed light on the significance of early transcriptomic and immune cell modulation in predicting responses to cemiplimab therapy. Additionally, our data suggest that IL8 levels in peripheral blood offer promising avenues for personalized treatment selection and response assessment in patients with cSCC receiving cemiplimab, while PD1+Tregs can be followed longitudinally to monitor response to therapy.
Authors
- Gianfranco Orlandino
- Stefania Belli (ORCID: https://orcid.org/0000-0002-8348-3313)
- Massimo Mascolo (ORCID: https://orcid.org/0000-0002-2576-220X)
- Teresa Troiani (ORCID: https://orcid.org/0000-0002-0646-4901)
- Marcello Scala (ORCID: https://orcid.org/0000-0003-2194-7239)
- Daniela Esposito (ORCID: https://orcid.org/0000-0001-5211-9861)
- Angela Ianaro (ORCID: https://orcid.org/0000-0003-2520-9647)
- Roberto Bianco (ORCID: https://orcid.org/0000-0003-3311-260X)
- Luigi Formisano (ORCID: https://orcid.org/0000-0001-7205-5105)
- Silvia Varricchio (ORCID: https://orcid.org/0000-0003-4984-0046)
- Annarita Amato
- Giuseppe Ercolano (ORCID: https://orcid.org/0000-0001-6026-2588)
- Daniela Claudia Maresca
- Alessandro Villa (ORCID: https://orcid.org/0000-0002-1966-6000)
- Alberto Servetto (ORCID: https://orcid.org/0000-0003-3624-224X)
- Giuseppe Attanasio (ORCID: https://orcid.org/0000-0001-8953-7610)
- Daniela Russo (ORCID: https://orcid.org/0000-0002-6961-3695)
- Massimiliano Scalvenzi (ORCID: https://orcid.org/0000-0002-9912-3611)
- Claudia Maria Ascione (ORCID: https://orcid.org/0009-0000-9454-2828)
- Fabiana Napolitano (ORCID: https://orcid.org/0000-0002-2463-8952)
- Angela Vallefuoco
- Fabio Somma
- Claudia Costa
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/jitc-2024-010421
- Citations
- 8
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.83
Funders
- Eli Lilly and Company
- Plan National Cancer
- Associazione Italiana per la Ricerca sul Cancro
- Ministero dell'Università e della Ricerca