Complement proteins in axial spondyloarthritis: associations with disease activity and TNFi treatment response in a multicentre RCT
In this study, complement LPPs L-ficolin, M-ficolin, and MASP-2 levels decrease following initiation of TNFi therapy, whereas alternative pathway critical component MASP-3 increases. Baseline L-ficolin and C3dg correlated positively with ASDAS-CRP, potentially by CRP influence. Nevertheless, baseline C3dg levels were associated with treatment response (ASDAS-CRP <1.3) at week 12. Our results provide important perspectives on the inflammatory processes in axSpA, shedding light on the involvement of the complement system related to disease activity, treatment response, and potentially to prognosis.
Authors
- Burkhard Muche (ORCID: https://orcid.org/0000-0003-4104-5080)
- Steffen Thiel (ORCID: https://orcid.org/0000-0002-4817-155X)
- Valeria Ríos Rodríguez (ORCID: https://orcid.org/0000-0001-5612-043X)
- Denis Poddubnyy (ORCID: https://orcid.org/0000-0002-4537-6015)
- Anne Gitte Loft (ORCID: https://orcid.org/0000-0001-6374-841X)
- Mikhail Protopopov (ORCID: https://orcid.org/0000-0003-4840-5069)
- Joachim Listing
- Fabian Proft (ORCID: https://orcid.org/0000-0003-4306-033X)
- Anne Troldborg (ORCID: https://orcid.org/0000-0002-9501-1268)
- Clara Mistegaard (ORCID: https://orcid.org/0000-0002-6359-2192)
- Murat Torğutalp (ORCID: https://orcid.org/0000-0003-4600-9484)
- Joachim Sieper (ORCID: https://orcid.org/0000-0003-0285-9890)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Rheumatology Advances in Practice
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/rap/rkaf007
- Citations
- 2
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91