Formulation and Evaluation of Naproxen Sodium 220 Mg Modified Release Tablet Using Novel Technology

Development of an experimental design (DOE) aimed at enhancing the modified release formulation of Naproxen Sodium 220 mg through innovative technology. This experimental approach focuses on improving the assay of Naproxen Sodium release tablets by incorporating DisintegrantsValidation of this method will encompass the processes of raw material dispensing, sifting, dry mixing, binder preparation, wet mixing, drying, milling, lubrication, compression. This study illustrates that the solid dispersion technique can significantly enhance the dissolution rate of Naproxen. The results are consistent with numerous other investigations into solid dispersion methods, indicating that this strategy serves as a viable option for pharmaceutical companies seeking to prolong the life cycle of products that exhibit poor solubility. A comparative analysis of the dissolution profiles was performed across various media, both with and without surfactants. The findings clearly demonstrate that an increase in the concentration of Disintegrants does not lead to interactions with the drug when combined with other excipients, thereby facilitating sustained drug delivery over prolonged periods. The improved formulation, developed through factorial design, can be administered as a single daily dose. The experimental design lays the groundwork for further optimization. In this investigation, Trial #3 emerged as the formulation that most effectively satisfies all criteria for an optimal formulation